Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC060
Test administered by neuromedic@manusdevices.net
Test date and time 2022-10-05 12:42
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient tbl madopar 250mg 1\2+ 1\4+1\2+1\4 caps Madopar HBS 1x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 25 individuals with a value less than 0.6 were subsequently diagnosed with PD. That is, 59.52% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.6 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 11, 'TN': 10, 'TP': 31, 'FP': 20}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 3, 'TN': 4, 'TP': 39, 'FP': 26}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 29, 'TN': 25, 'TP': 13, 'FP': 5}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 5.636
timePerCircleCoV 0.281324
timePerCircleSlope -0.0580252
meanError 2.15959
tremorFreq 6.25
tremorRelPower 39.0133
tremorGyroAmpMean 0.0564488
tremorGyroAmpSlope 0.00712796
tremorGyroAmpCoV 0.393471
tremorCoordAmpMean 0.0831009
tremorCoordAmpSlope 0.00875096
tremorCoordAmpCoV 0.334212
tremorAccAmpMean 0.10059
tremorAccAmpSlope 0.00377191
tremorAccAmpCoV 0.185052
tremorPcRelVar 0.696331
tremorPcX -0.803404
tremorPcY -0.595435

Circle Segment 1

Duration 5.88 s, Accuracy Estimate 2.301 (lower is better)

Circle Segment 2

Duration 7.08 s, Accuracy Estimate 1.573 (lower is better)

Circle Segment 3

Duration 5.64 s, Accuracy Estimate 1.962 (lower is better)

Circle Segment 4

Duration 6.32 s, Accuracy Estimate 1.62 (lower is better)

Circle Segment 5

Duration 8.72 s, Accuracy Estimate 2.234 (lower is better)

Circle Segment 6

Duration 4.52 s, Accuracy Estimate 2.685 (lower is better)

Circle Segment 7

Duration 5.88 s, Accuracy Estimate 2.066 (lower is better)

Circle Segment 8

Duration 5.28 s, Accuracy Estimate 2.093 (lower is better)

Circle Segment 9

Duration 3.76 s, Accuracy Estimate 1.977 (lower is better)

Circle Segment 10

Duration 3.28 s, Accuracy Estimate 3.084 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 16.064
timePerSpiralCoV 0.153079
timePerSpiralSlope -0.00522154
meanError 1.89572
tremorFreq 6.15234
tremorRelPower 35.5668
tremorGyroAmpMean 0.0578073
tremorGyroAmpSlope 0.00166197
tremorGyroAmpCoV 0.468062
tremorCoordAmpMean 0.107389
tremorCoordAmpSlope -0.000626804
tremorCoordAmpCoV 0.520819
tremorAccAmpMean 0.115937
tremorAccAmpSlope -0.000168414
tremorAccAmpCoV 0.339298
tremorPcRelVar 0.6238
tremorPcX 0.784676
tremorPcY -0.619906

Spiral Segment 1

Duration 21.08 s, Accuracy Estimate 1.438 (lower is better)

Spiral Segment 2

Duration 16.52 s, Accuracy Estimate 1.839 (lower is better)

Spiral Segment 3

Duration 14.24 s, Accuracy Estimate 1.901 (lower is better)

Spiral Segment 4

Duration 12.68 s, Accuracy Estimate 1.94 (lower is better)

Spiral Segment 5

Duration 15.88 s, Accuracy Estimate 2.006 (lower is better)

Spiral Segment 6

Duration 14.2 s, Accuracy Estimate 2.433 (lower is better)

Spiral Segment 7

Duration 14.24 s, Accuracy Estimate 2.083 (lower is better)

Spiral Segment 8

Duration 17.4 s, Accuracy Estimate 1.673 (lower is better)

Spiral Segment 9

Duration 18.44 s, Accuracy Estimate 1.797 (lower is better)

Spiral Segment 10

Duration 15.96 s, Accuracy Estimate 1.847 (lower is better)

Elel

eDurationMean 1.06581
eDurationStd 0.372826
eDurationStdnorm 0.349805
eDurationMedian 0.93
eDurationQuartdelta 0.39
eDurationQuartdeltanorm 0.419355
eDurationKurt 3.9677
eDurationTrenddiff -0.29
eDurationTrendratio 0.748373
eWidthMean 4.41438
eWidthStd 1.35988
eWidthStdnorm 0.308057
eWidthMedian 4.329
eWidthQuartdelta 1.25775
eWidthQuartdeltanorm 0.290541
eWidthKurt 3.84869
eWidthTrenddiff -0.6435
eWidthTrendratio 0.853333
eHeightMean 7.89908
eHeightStd 1.7471
eHeightStdnorm 0.221178
eHeightMedian 7.371
eHeightQuartdelta 2.19375
eHeightQuartdeltanorm 0.297619
eHeightKurt 4.31868
eHeightTrenddiff -1.404
eHeightTrendratio 0.835616
eAspectMean 0.556922
eAspectStd 0.100732
eAspectStdnorm 0.180873
eAspectMedian 0.545455
eAspectQuartdelta 0.151949
eAspectQuartdeltanorm 0.278574
eAspectKurt 2.59136
eAspectTrenddiff -0.0178945
eAspectTrendratio 0.96742
eSlantMean 0.110869
eSlantStd 0.161498
eSlantStdnorm 1.45665
eSlantMedian 0.109091
eSlantQuartdelta 0.185506
eSlantQuartdeltanorm 1.70047
eSlantKurt 3.61823
eSlantTrenddiff 0.100611
eRtopMean 0.696846
eRtopStd 0.138371
eRtopStdnorm 0.198567
eRtopMedian 0.688889
eRtopQuartdelta 0.203779
eRtopQuartdeltanorm 0.295809
eRtopKurt 2.00679
eRtopTrenddiff -0.0711174
eRbotMean 0.506122
eRbotStd 0.231641
eRbotStdnorm 0.457677
eRbotMedian 0.516129
eRbotQuartdelta 0.319029
eRbotQuartdeltanorm 0.61812
eRbotKurt 2.64254
eRbotTrenddiff -0.263048
eRrightMean 0.821261
eRrightStd 0.0818988
eRrightStdnorm 0.0997232
eRrightMedian 0.835443
eRrightQuartdelta 0.114806
eRrightQuartdeltanorm 0.13742
eRrightKurt 2.38558
eRrightTrenddiff 0.0358257
eRleftMean 0.311346
eRleftStd 0.11383
eRleftStdnorm 0.365605
eRleftMedian 0.307692
eRleftQuartdelta 0.11125
eRleftQuartdeltanorm 0.361561
eRleftKurt 3.19186
eRleftTrenddiff -0.0177428
lDurationMean 1.45025
lDurationStd 0.487353
lDurationStdnorm 0.336047
lDurationMedian 1.3375
lDurationQuartdelta 0.2975
lDurationQuartdeltanorm 0.22243
lDurationKurt 6.68104
lDurationTrenddiff -0.1525
lDurationTrendratio 0.890877
lWidthMean 9.52965
lWidthStd 3.00601
lWidthStdnorm 0.315438
lWidthMedian 9.0675
lWidthQuartdelta 3.276
lWidthQuartdeltanorm 0.36129
lWidthKurt 2.85278
lWidthTrenddiff -0.0585
lWidthTrendratio 0.993548
lHeightMean 20.2059
lHeightStd 3.79097
lHeightStdnorm 0.187617
lHeightMedian 19.656
lHeightQuartdelta 4.914
lHeightQuartdeltanorm 0.25
lHeightKurt 2.94932
lHeightTrenddiff -2.3985
lHeightTrendratio 0.888283
lAspectMean 0.472618
lAspectStd 0.114276
lAspectStdnorm 0.241794
lAspectMedian 0.466185
lAspectQuartdelta 0.165462
lAspectQuartdeltanorm 0.354927
lAspectKurt 2.7511
lAspectTrenddiff 0.00444806
lAspectTrendratio 1.00959
lSlantMean 0.321723
lSlantStd 0.136929
lSlantStdnorm 0.425611
lSlantMedian 0.324707
lSlantQuartdelta 0.175971
lSlantQuartdeltanorm 0.541939
lSlantKurt 3.77652
lSlantTrenddiff 0.00514651
lRtopMean 0.877118
lRtopStd 0.116805
lRtopStdnorm 0.133169
lRtopMedian 0.910147
lRtopQuartdelta 0.0874689
lRtopQuartdeltanorm 0.0961042
lRtopKurt 7.56564
lRtopTrenddiff 0.0121391
lRbotMean 0.229798
lRbotStd 0.147611
lRbotStdnorm 0.642352
lRbotMedian 0.189992
lRbotQuartdelta 0.120323
lRbotQuartdeltanorm 0.633304
lRbotKurt 7.33439
lRbotTrenddiff -0.0259462
lRrightMean 0.931034
lRrightStd 0.0583164
lRrightStdnorm 0.0626362
lRrightMedian 0.93813
lRrightQuartdelta 0.0702637
lRrightQuartdeltanorm 0.0748976
lRrightKurt 6.62247
lRrightTrenddiff -0.00115763
lRleftMean 0.138328
lRleftStd 0.123172
lRleftStdnorm 0.890435
lRleftMedian 0.105437
lRleftQuartdelta 0.0924698
lRleftQuartdeltanorm 0.877017
lRleftKurt 9.43473
lRleftTrenddiff -0.0515538

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

FITTS Short Modified

meanTouchScore 0.983874
sumTouchScores 18.6936
meanMovementTime 0.961667
numTouches 19
undershootPercentage 0
overshootPercentage 5.26316

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.894635
sumTouchScores 16.1034
meanMovementTime 1.04029
numTouches 18
undershootPercentage 5.55556
overshootPercentage 11.1111

ZigZag

numZigzags 5
timePerZigzagMean 24.84
timePerZigzagCoV 0.189852
timePerZigzagSlope 0.118196
meanError 2.55879
tremorFreq 6.54297
tremorRelPower 27.9845
tremorGyroAmpMean 0.0538717
tremorGyroAmpSlope 0.000479653
tremorGyroAmpCoV 0.363607
tremorCoordAmpMean 0.122431
tremorCoordAmpSlope -0.00175445
tremorCoordAmpCoV 0.417721
tremorAccAmpMean 0.112734
tremorAccAmpSlope -0.00167946
tremorAccAmpCoV 0.442298
tremorPcRelVar 0.70523
tremorPcX 0.481833
tremorPcY 0.876263

ZigZag Segment 1

Duration 20.0 s, Accuracy Estimate 2.569 (lower is better)

ZigZag Segment 2

Duration 21.04 s, Accuracy Estimate 2.454 (lower is better)

ZigZag Segment 3

Duration 24.12 s, Accuracy Estimate 2.45 (lower is better)

ZigZag Segment 4

Duration 27.68 s, Accuracy Estimate 2.481 (lower is better)

ZigZag Segment 5

Duration 31.36 s, Accuracy Estimate 2.84 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 25.856
timePerZigzagCoV 0.133742
timePerZigzagSlope -0.0360458
zigzagHeightMean 41.0636
zigzagHeightCoV 0.130215
zigzagHeightSlope -0.0657095
meanError 0.042537
tremorFreq 6.44531
tremorRelPower 21.528
tremorGyroAmpMean 0.0621155
tremorGyroAmpSlope 0.00124642
tremorGyroAmpCoV 0.391542
tremorCoordAmpMean 0.0963048
tremorCoordAmpSlope -0.000160741
tremorCoordAmpCoV 0.489055
tremorAccAmpMean 0.0838374
tremorAccAmpSlope 0.000766091
tremorAccAmpCoV 0.414309
tremorPcRelVar 0.690859
tremorPcX -0.0206266
tremorPcY 0.999787

ZigZag Offset Segment 1

Duration 24.52 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 2

Duration 32.0 s, Accuracy Estimate 0.051 (lower is better)

ZigZag Offset Segment 3

Duration 24.68 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 4

Duration 24.44 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 5

Duration 23.64 s, Accuracy Estimate 0.046 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.87}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.6}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.1077320391034291}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9268501385459491}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.48244808916446935}